Where are you in the space of your piece? Where do you want your audience to be? Do you want them horizontal, vertical, do you want where they are to change over time? Where do you want your sound source options to come from? How do you experience sound in the space? Voice from vocals, instruments, objects, moving sculptures. Where are these sound placed during the piece, are they moving througought the piece? Is the audience sitting on the stage? Do you want to use music? Do you want to include a soundscape?